Toward a theory-based specification of non-pharmacological treatments in aging and dementia: Focused reviews and methodological recommendations.
Identifieur interne : 000010 ( Main/Exploration ); précédent : 000009; suivant : 000011Toward a theory-based specification of non-pharmacological treatments in aging and dementia: Focused reviews and methodological recommendations.
Auteurs : Sietske A M. Sikkes [Pays-Bas] ; Yi Tang [République populaire de Chine] ; Roos J. Jutten [Pays-Bas] ; Linda M P. Wesselman [Pays-Bas] ; Lyn S. Turkstra [Canada] ; Henry Brodaty [Australie] ; Linda Clare [Royaume-Uni] ; Erin Cassidy-Eagle [États-Unis] ; Kay L. Cox [Australie] ; Gaël Chételat [France] ; Sophie Dautricourt [France] ; Klodian Dhana [États-Unis] ; Hiroko Dodge [États-Unis] ; Rose-Marie Dröes [Pays-Bas] ; Benjamin M. Hampstead [États-Unis] ; Thomas Holland [États-Unis] ; Amit Lampit [Australie] ; Kate Laver [Australie] ; Antoine Lutz [France] ; Nicola T. Lautenschlager [Australie] ; Susan M. Mccurry [États-Unis] ; Franka J M. Meiland [Pays-Bas] ; Martha Clare Morris [États-Unis] ; Kimberly D. Mueller [États-Unis] ; Ruth Peters [Australie] ; Gemma Ridel [Royaume-Uni] ; Aimee Spector [Royaume-Uni] ; Jenny T. Van Der Steen [Pays-Bas] ; Jeanette Tamplin [Australie] ; Zara Thompson [Australie] ; Alex Bahar-Fuchs [Australie]Source :
- Alzheimer's & dementia : the journal of the Alzheimer's Association [ 1552-5279 ] ; 2021.
Abstract
INTRODUCTION
Non-pharmacological treatments (NPTs) have the potential to improve meaningful outcomes for older people at risk of, or living with dementia, but research often lacks methodological rigor and continues to produce mixed results.
METHODS
In the current position paper, experts in NPT research have specified treatment targets, aims, and ingredients using an umbrella framework, the Rehabilitation Treatment Specification System.
RESULTS
Experts provided a snapshot and an authoritative summary of the evidence for different NPTs based on the best synthesis efforts, identified main gaps in knowledge and relevant barriers, and provided directions for future research. Experts in trial methodology provide best practice principles and recommendations for those working in this area, underscoring the importance of prespecified protocols.
DISCUSSION
We conclude that the evidence strongly supports various NPTs in relation to their primary targets, and discuss opportunities and challenges associated with a unifying theoretical framework to guide future efforts in this area.
DOI: 10.1002/alz.12188
PubMed: 33215876
Affiliations:
- Australie, Canada, France, Pays-Bas, Royaume-Uni, République populaire de Chine, États-Unis
- Angleterre, Auvergne-Rhône-Alpes, Basse-Normandie, Californie, Grand Londres, Gueldre, Hollande-Méridionale, Hollande-Septentrionale, Illinois, Michigan, Nouvelle-Galles du Sud, Ontario, Oregon, Rhône-Alpes, Région Normandie, Victoria (État), Washington (État), Wisconsin
- Amsterdam, Caen, Hamilton (Ontario), Leyde, Londres, Lyon, Melbourne, Nimègue, Pékin, Seattle, Sydney
- University College de Londres, Université McMaster, Université de Melbourne, Université de Washington
Links toward previous steps (curation, corpus...)
Le document en format XML
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Sikkes</name><affiliation wicri:level="3"><nlm:affiliation>Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, VU University Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical, Neuro- and Developmental Psychology, VU University, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Clinical, Neuro- and Developmental Psychology, VU University, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Tang, Yi" sort="Tang, Yi" uniqKey="Tang Y" first="Yi" last="Tang">Yi Tang</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jutten, Roos J" sort="Jutten, Roos J" uniqKey="Jutten R" first="Roos J" last="Jutten">Roos J. Jutten</name><affiliation wicri:level="3"><nlm:affiliation>Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, VU University Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical, Neuro- and Developmental Psychology, VU University, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Clinical, Neuro- and Developmental Psychology, VU University, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Wesselman, Linda M P" sort="Wesselman, Linda M P" uniqKey="Wesselman L" first="Linda M P" last="Wesselman">Linda M P. Wesselman</name><affiliation wicri:level="3"><nlm:affiliation>Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, VU University Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical, Neuro- and Developmental Psychology, VU University, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Clinical, Neuro- and Developmental Psychology, VU University, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Turkstra, Lyn S" sort="Turkstra, Lyn S" uniqKey="Turkstra L" first="Lyn S" last="Turkstra">Lyn S. Turkstra</name><affiliation wicri:level="4"><nlm:affiliation>School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>School of Rehabilitation Science, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Brodaty, Henry" sort="Brodaty, Henry" uniqKey="Brodaty H" first="Henry" last="Brodaty">Henry Brodaty</name><affiliation wicri:level="3"><nlm:affiliation>Centre for Healthy Brain Ageing and Dementia Centre for Research Collaboration, School of Psychiatry, UNSW, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Healthy Brain Ageing and Dementia Centre for Research Collaboration, School of Psychiatry, UNSW, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Clare, Linda" sort="Clare, Linda" uniqKey="Clare L" first="Linda" last="Clare">Linda Clare</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Research in Ageing and Cognitive Health, College of Medicine and Health, University of Exeter, Exeter, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Research in Ageing and Cognitive Health, College of Medicine and Health, University of Exeter, Exeter</wicri:regionArea><wicri:noRegion>Exeter</wicri:noRegion></affiliation></author><author><name sortKey="Cassidy Eagle, Erin" sort="Cassidy Eagle, Erin" uniqKey="Cassidy Eagle E" first="Erin" last="Cassidy-Eagle">Erin Cassidy-Eagle</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Cox, Kay L" sort="Cox, Kay L" uniqKey="Cox K" first="Kay L" last="Cox">Kay L. Cox</name><affiliation wicri:level="1"><nlm:affiliation>Medical School, University of Western Australia, Perth, Western Australia, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Medical School, University of Western Australia, Perth, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gaël" last="Chételat">Gaël Chételat</name><affiliation wicri:level="3"><nlm:affiliation>Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders,", Institut Blood and Brain @ Caen-Normandie, Cyceron, Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders,", Institut Blood and Brain @ Caen-Normandie, Cyceron, Caen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Dautricourt, Sophie" sort="Dautricourt, Sophie" uniqKey="Dautricourt S" first="Sophie" last="Dautricourt">Sophie Dautricourt</name><affiliation wicri:level="3"><nlm:affiliation>Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders,", Institut Blood and Brain @ Caen-Normandie, Cyceron, Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders,", Institut Blood and Brain @ Caen-Normandie, Cyceron, Caen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Dhana, Klodian" sort="Dhana, Klodian" uniqKey="Dhana K" first="Klodian" last="Dhana">Klodian Dhana</name><affiliation wicri:level="2"><nlm:affiliation>Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush University, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush University, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Dodge, Hiroko" sort="Dodge, Hiroko" uniqKey="Dodge H" first="Hiroko" last="Dodge">Hiroko Dodge</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Oregon Health and Science University, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Michigan, Ann Arbor, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Droes, Rose Marie" sort="Droes, Rose Marie" uniqKey="Droes R" first="Rose-Marie" last="Dröes">Rose-Marie Dröes</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Amsterdam University Medical Center, VUmc, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Amsterdam University Medical Center, VUmc, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Hampstead, Benjamin M" sort="Hampstead, Benjamin M" uniqKey="Hampstead B" first="Benjamin M" last="Hampstead">Benjamin M. Hampstead</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, Michigan, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Holland, Thomas" sort="Holland, Thomas" uniqKey="Holland T" first="Thomas" last="Holland">Thomas Holland</name><affiliation wicri:level="2"><nlm:affiliation>Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush University, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush University, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Lampit, Amit" sort="Lampit, Amit" uniqKey="Lampit A" first="Amit" last="Lampit">Amit Lampit</name><affiliation wicri:level="4"><nlm:affiliation>Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Laver, Kate" sort="Laver, Kate" uniqKey="Laver K" first="Kate" last="Laver">Kate Laver</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation, Aged and Extended Care, College of Medicine and Public Health, Flinders University, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Rehabilitation, Aged and Extended Care, College of Medicine and Public Health, Flinders University, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Lutz, Antoine" sort="Lutz, Antoine" uniqKey="Lutz A" first="Antoine" last="Lutz">Antoine Lutz</name><affiliation wicri:level="3"><nlm:affiliation>Lyon Neuroscience Research Center INSERM U1028, CNRS UMR5292, Lyon University, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Lyon Neuroscience Research Center INSERM U1028, CNRS UMR5292, Lyon University, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Lautenschlager, Nicola T" sort="Lautenschlager, Nicola T" uniqKey="Lautenschlager N" first="Nicola T" last="Lautenschlager">Nicola T. Lautenschlager</name><affiliation wicri:level="4"><nlm:affiliation>Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>NorthWestern Mental Health, Melbourne Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>NorthWestern Mental Health, Melbourne Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Mccurry, Susan M" sort="Mccurry, Susan M" uniqKey="Mccurry S" first="Susan M" last="Mccurry">Susan M. Mccurry</name><affiliation wicri:level="4"><nlm:affiliation>Department of Child, Family, and Population Health Nursing, University of Washington, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Child, Family, and Population Health Nursing, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Meiland, Franka J M" sort="Meiland, Franka J M" uniqKey="Meiland F" first="Franka J M" last="Meiland">Franka J M. Meiland</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Amsterdam University Medical Center, VUmc, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Amsterdam University Medical Center, VUmc, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Morris, Martha Clare" sort="Morris, Martha Clare" uniqKey="Morris M" first="Martha Clare" last="Morris">Martha Clare Morris</name><affiliation wicri:level="2"><nlm:affiliation>Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush University, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush University, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Mueller, Kimberly D" sort="Mueller, Kimberly D" uniqKey="Mueller K" first="Kimberly D" last="Mueller">Kimberly D. Mueller</name><affiliation wicri:level="2"><nlm:affiliation>Wisconsin Alzheimer's Institute, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wisconsin Alzheimer's Institute, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Peters, Ruth" sort="Peters, Ruth" uniqKey="Peters R" first="Ruth" last="Peters">Ruth Peters</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychology, University of New South Wales, Randwick, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Psychology, University of New South Wales, Randwick, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Neuroscience Research Australia, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Neuroscience Research Australia, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Ridel, Gemma" sort="Ridel, Gemma" uniqKey="Ridel G" first="Gemma" last="Ridel">Gemma Ridel</name><affiliation wicri:level="1"><nlm:affiliation>The University of East Anglia, Norwich, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The University of East Anglia, Norwich</wicri:regionArea><wicri:noRegion>Norwich</wicri:noRegion></affiliation></author><author><name sortKey="Spector, Aimee" sort="Spector, Aimee" uniqKey="Spector A" first="Aimee" last="Spector">Aimee Spector</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical, Educational & Health Psychology, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical, Educational & Health Psychology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Van Der Steen, Jenny T" sort="Van Der Steen, Jenny T" uniqKey="Van Der Steen J" first="Jenny T" last="Van Der Steen">Jenny T. Van Der Steen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Public Health and Primary Care, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Primary and Community Care, Radboud University Medical Center, Nijmegen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Primary and Community Care, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Tamplin, Jeanette" sort="Tamplin, Jeanette" uniqKey="Tamplin J" first="Jeanette" last="Tamplin">Jeanette Tamplin</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Fine Arts and Music, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Fine Arts and Music, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Thompson, Zara" sort="Thompson, Zara" uniqKey="Thompson Z" first="Zara" last="Thompson">Zara Thompson</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Fine Arts and Music, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Fine Arts and Music, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Bahar Fuchs, Alex" sort="Bahar Fuchs, Alex" uniqKey="Bahar Fuchs A" first="Alex" last="Bahar-Fuchs">Alex Bahar-Fuchs</name><affiliation wicri:level="4"><nlm:affiliation>Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre for Research on Ageing, Health, and Wellbeing, Research School of Population Health, The Australian National University, Canberra, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Research on Ageing, Health, and Wellbeing, Research School of Population Health, The Australian National University, Canberra</wicri:regionArea><wicri:noRegion>Canberra</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33215876</idno><idno type="pmid">33215876</idno><idno type="doi">10.1002/alz.12188</idno><idno type="wicri:Area/Main/Corpus">000106</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000106</idno><idno type="wicri:Area/Main/Curation">000106</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000106</idno><idno type="wicri:Area/Main/Exploration">000106</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Toward a theory-based specification of non-pharmacological treatments in aging and dementia: Focused reviews and methodological recommendations.</title><author><name sortKey="Sikkes, Sietske A M" sort="Sikkes, Sietske A M" uniqKey="Sikkes S" first="Sietske A M" last="Sikkes">Sietske A M. Sikkes</name><affiliation wicri:level="3"><nlm:affiliation>Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, VU University Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical, Neuro- and Developmental Psychology, VU University, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Clinical, Neuro- and Developmental Psychology, VU University, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Tang, Yi" sort="Tang, Yi" uniqKey="Tang Y" first="Yi" last="Tang">Yi Tang</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jutten, Roos J" sort="Jutten, Roos J" uniqKey="Jutten R" first="Roos J" last="Jutten">Roos J. Jutten</name><affiliation wicri:level="3"><nlm:affiliation>Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, VU University Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical, Neuro- and Developmental Psychology, VU University, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Clinical, Neuro- and Developmental Psychology, VU University, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Wesselman, Linda M P" sort="Wesselman, Linda M P" uniqKey="Wesselman L" first="Linda M P" last="Wesselman">Linda M P. Wesselman</name><affiliation wicri:level="3"><nlm:affiliation>Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, VU University Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, VU University Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical, Neuro- and Developmental Psychology, VU University, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Clinical, Neuro- and Developmental Psychology, VU University, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Turkstra, Lyn S" sort="Turkstra, Lyn S" uniqKey="Turkstra L" first="Lyn S" last="Turkstra">Lyn S. Turkstra</name><affiliation wicri:level="4"><nlm:affiliation>School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>School of Rehabilitation Science, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Brodaty, Henry" sort="Brodaty, Henry" uniqKey="Brodaty H" first="Henry" last="Brodaty">Henry Brodaty</name><affiliation wicri:level="3"><nlm:affiliation>Centre for Healthy Brain Ageing and Dementia Centre for Research Collaboration, School of Psychiatry, UNSW, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Healthy Brain Ageing and Dementia Centre for Research Collaboration, School of Psychiatry, UNSW, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Clare, Linda" sort="Clare, Linda" uniqKey="Clare L" first="Linda" last="Clare">Linda Clare</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Research in Ageing and Cognitive Health, College of Medicine and Health, University of Exeter, Exeter, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Research in Ageing and Cognitive Health, College of Medicine and Health, University of Exeter, Exeter</wicri:regionArea><wicri:noRegion>Exeter</wicri:noRegion></affiliation></author><author><name sortKey="Cassidy Eagle, Erin" sort="Cassidy Eagle, Erin" uniqKey="Cassidy Eagle E" first="Erin" last="Cassidy-Eagle">Erin Cassidy-Eagle</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Cox, Kay L" sort="Cox, Kay L" uniqKey="Cox K" first="Kay L" last="Cox">Kay L. Cox</name><affiliation wicri:level="1"><nlm:affiliation>Medical School, University of Western Australia, Perth, Western Australia, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Medical School, University of Western Australia, Perth, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gaël" last="Chételat">Gaël Chételat</name><affiliation wicri:level="3"><nlm:affiliation>Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders,", Institut Blood and Brain @ Caen-Normandie, Cyceron, Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders,", Institut Blood and Brain @ Caen-Normandie, Cyceron, Caen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Dautricourt, Sophie" sort="Dautricourt, Sophie" uniqKey="Dautricourt S" first="Sophie" last="Dautricourt">Sophie Dautricourt</name><affiliation wicri:level="3"><nlm:affiliation>Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders,", Institut Blood and Brain @ Caen-Normandie, Cyceron, Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders,", Institut Blood and Brain @ Caen-Normandie, Cyceron, Caen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Dhana, Klodian" sort="Dhana, Klodian" uniqKey="Dhana K" first="Klodian" last="Dhana">Klodian Dhana</name><affiliation wicri:level="2"><nlm:affiliation>Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush University, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush University, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Dodge, Hiroko" sort="Dodge, Hiroko" uniqKey="Dodge H" first="Hiroko" last="Dodge">Hiroko Dodge</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Oregon Health and Science University, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Michigan, Ann Arbor, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Droes, Rose Marie" sort="Droes, Rose Marie" uniqKey="Droes R" first="Rose-Marie" last="Dröes">Rose-Marie Dröes</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Amsterdam University Medical Center, VUmc, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Amsterdam University Medical Center, VUmc, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Hampstead, Benjamin M" sort="Hampstead, Benjamin M" uniqKey="Hampstead B" first="Benjamin M" last="Hampstead">Benjamin M. Hampstead</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, Michigan, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Holland, Thomas" sort="Holland, Thomas" uniqKey="Holland T" first="Thomas" last="Holland">Thomas Holland</name><affiliation wicri:level="2"><nlm:affiliation>Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush University, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush University, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Lampit, Amit" sort="Lampit, Amit" uniqKey="Lampit A" first="Amit" last="Lampit">Amit Lampit</name><affiliation wicri:level="4"><nlm:affiliation>Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Laver, Kate" sort="Laver, Kate" uniqKey="Laver K" first="Kate" last="Laver">Kate Laver</name><affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation, Aged and Extended Care, College of Medicine and Public Health, Flinders University, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Rehabilitation, Aged and Extended Care, College of Medicine and Public Health, Flinders University, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Lutz, Antoine" sort="Lutz, Antoine" uniqKey="Lutz A" first="Antoine" last="Lutz">Antoine Lutz</name><affiliation wicri:level="3"><nlm:affiliation>Lyon Neuroscience Research Center INSERM U1028, CNRS UMR5292, Lyon University, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Lyon Neuroscience Research Center INSERM U1028, CNRS UMR5292, Lyon University, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Lautenschlager, Nicola T" sort="Lautenschlager, Nicola T" uniqKey="Lautenschlager N" first="Nicola T" last="Lautenschlager">Nicola T. Lautenschlager</name><affiliation wicri:level="4"><nlm:affiliation>Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>NorthWestern Mental Health, Melbourne Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>NorthWestern Mental Health, Melbourne Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Mccurry, Susan M" sort="Mccurry, Susan M" uniqKey="Mccurry S" first="Susan M" last="Mccurry">Susan M. Mccurry</name><affiliation wicri:level="4"><nlm:affiliation>Department of Child, Family, and Population Health Nursing, University of Washington, Seattle, Washington, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Child, Family, and Population Health Nursing, University of Washington, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Meiland, Franka J M" sort="Meiland, Franka J M" uniqKey="Meiland F" first="Franka J M" last="Meiland">Franka J M. Meiland</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Amsterdam University Medical Center, VUmc, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Amsterdam University Medical Center, VUmc, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Morris, Martha Clare" sort="Morris, Martha Clare" uniqKey="Morris M" first="Martha Clare" last="Morris">Martha Clare Morris</name><affiliation wicri:level="2"><nlm:affiliation>Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush University, Chicago, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush University, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Mueller, Kimberly D" sort="Mueller, Kimberly D" uniqKey="Mueller K" first="Kimberly D" last="Mueller">Kimberly D. Mueller</name><affiliation wicri:level="2"><nlm:affiliation>Wisconsin Alzheimer's Institute, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Wisconsin Alzheimer's Institute, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Peters, Ruth" sort="Peters, Ruth" uniqKey="Peters R" first="Ruth" last="Peters">Ruth Peters</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychology, University of New South Wales, Randwick, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Psychology, University of New South Wales, Randwick, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Neuroscience Research Australia, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Neuroscience Research Australia, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Ridel, Gemma" sort="Ridel, Gemma" uniqKey="Ridel G" first="Gemma" last="Ridel">Gemma Ridel</name><affiliation wicri:level="1"><nlm:affiliation>The University of East Anglia, Norwich, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The University of East Anglia, Norwich</wicri:regionArea><wicri:noRegion>Norwich</wicri:noRegion></affiliation></author><author><name sortKey="Spector, Aimee" sort="Spector, Aimee" uniqKey="Spector A" first="Aimee" last="Spector">Aimee Spector</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical, Educational & Health Psychology, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical, Educational & Health Psychology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Van Der Steen, Jenny T" sort="Van Der Steen, Jenny T" uniqKey="Van Der Steen J" first="Jenny T" last="Van Der Steen">Jenny T. Van Der Steen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Public Health and Primary Care, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Primary and Community Care, Radboud University Medical Center, Nijmegen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Primary and Community Care, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Tamplin, Jeanette" sort="Tamplin, Jeanette" uniqKey="Tamplin J" first="Jeanette" last="Tamplin">Jeanette Tamplin</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Fine Arts and Music, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Fine Arts and Music, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Thompson, Zara" sort="Thompson, Zara" uniqKey="Thompson Z" first="Zara" last="Thompson">Zara Thompson</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Fine Arts and Music, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Fine Arts and Music, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Bahar Fuchs, Alex" sort="Bahar Fuchs, Alex" uniqKey="Bahar Fuchs A" first="Alex" last="Bahar-Fuchs">Alex Bahar-Fuchs</name><affiliation wicri:level="4"><nlm:affiliation>Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre for Research on Ageing, Health, and Wellbeing, Research School of Population Health, The Australian National University, Canberra, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Research on Ageing, Health, and Wellbeing, Research School of Population Health, The Australian National University, Canberra</wicri:regionArea><wicri:noRegion>Canberra</wicri:noRegion></affiliation></author></analytic><series><title level="j">Alzheimer's & dementia : the journal of the Alzheimer's Association</title><idno type="eISSN">1552-5279</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b></p><p>Non-pharmacological treatments (NPTs) have the potential to improve meaningful outcomes for older people at risk of, or living with dementia, but research often lacks methodological rigor and continues to produce mixed results.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>In the current position paper, experts in NPT research have specified treatment targets, aims, and ingredients using an umbrella framework, the Rehabilitation Treatment Specification System.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Experts provided a snapshot and an authoritative summary of the evidence for different NPTs based on the best synthesis efforts, identified main gaps in knowledge and relevant barriers, and provided directions for future research. Experts in trial methodology provide best practice principles and recommendations for those working in this area, underscoring the importance of prespecified protocols.</p></div><div type="abstract" xml:lang="en"><p><b>DISCUSSION</b></p><p>We conclude that the evidence strongly supports various NPTs in relation to their primary targets, and discuss opportunities and challenges associated with a unifying theoretical framework to guide future efforts in this area.</p></div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">33215876</PMID><DateRevised><Year>2021</Year><Month>03</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1552-5279</ISSN><JournalIssue CitedMedium="Internet"><Volume>17</Volume><Issue>2</Issue><PubDate><Year>2021</Year><Month>02</Month></PubDate></JournalIssue><Title>Alzheimer's & dementia : the journal of the Alzheimer's Association</Title><ISOAbbreviation>Alzheimers Dement</ISOAbbreviation></Journal><ArticleTitle>Toward a theory-based specification of non-pharmacological treatments in aging and dementia: Focused reviews and methodological recommendations.</ArticleTitle><Pagination><MedlinePgn>255-270</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/alz.12188</ELocationID><Abstract><AbstractText Label="INTRODUCTION">Non-pharmacological treatments (NPTs) have the potential to improve meaningful outcomes for older people at risk of, or living with dementia, but research often lacks methodological rigor and continues to produce mixed results.</AbstractText><AbstractText Label="METHODS">In the current position paper, experts in NPT research have specified treatment targets, aims, and ingredients using an umbrella framework, the Rehabilitation Treatment Specification System.</AbstractText><AbstractText Label="RESULTS">Experts provided a snapshot and an authoritative summary of the evidence for different NPTs based on the best synthesis efforts, identified main gaps in knowledge and relevant barriers, and provided directions for future research. Experts in trial methodology provide best practice principles and recommendations for those working in this area, underscoring the importance of prespecified protocols.</AbstractText><AbstractText Label="DISCUSSION">We conclude that the evidence strongly supports various NPTs in relation to their primary targets, and discuss opportunities and challenges associated with a unifying theoretical framework to guide future efforts in this area.</AbstractText><CopyrightInformation>© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sikkes</LastName><ForeName>Sietske A M</ForeName><Initials>SAM</Initials><AffiliationInfo><Affiliation>Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, VU University Amsterdam, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Clinical, Neuro- and Developmental Psychology, VU University, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Yi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jutten</LastName><ForeName>Roos J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, VU University Amsterdam, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Clinical, Neuro- and Developmental Psychology, VU University, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wesselman</LastName><ForeName>Linda M P</ForeName><Initials>LMP</Initials><AffiliationInfo><Affiliation>Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center, VU University Amsterdam, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Clinical, Neuro- and Developmental Psychology, VU University, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Turkstra</LastName><ForeName>Lyn S</ForeName><Initials>LS</Initials><AffiliationInfo><Affiliation>School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brodaty</LastName><ForeName>Henry</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Centre for Healthy Brain Ageing and Dementia Centre for Research Collaboration, School of Psychiatry, UNSW, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clare</LastName><ForeName>Linda</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Centre for Research in Ageing and Cognitive Health, College of Medicine and Health, University of Exeter, Exeter, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cassidy-Eagle</LastName><ForeName>Erin</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cox</LastName><ForeName>Kay L</ForeName><Initials>KL</Initials><AffiliationInfo><Affiliation>Medical School, University of Western Australia, Perth, Western Australia, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chételat</LastName><ForeName>Gaël</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders,", Institut Blood and Brain @ Caen-Normandie, Cyceron, Caen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dautricourt</LastName><ForeName>Sophie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Normandie Univ, UNICAEN, INSERM, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders,", Institut Blood and Brain @ Caen-Normandie, Cyceron, Caen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dhana</LastName><ForeName>Klodian</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush University, Chicago, Illinois, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dodge</LastName><ForeName>Hiroko</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dröes</LastName><ForeName>Rose-Marie</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Amsterdam University Medical Center, VUmc, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hampstead</LastName><ForeName>Benjamin M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Michigan and VA Ann Arbor Healthcare System, Ann Arbor, Michigan, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holland</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush University, Chicago, Illinois, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lampit</LastName><ForeName>Amit</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laver</LastName><ForeName>Kate</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Rehabilitation, Aged and Extended Care, College of Medicine and Public Health, Flinders University, Adelaide, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lutz</LastName><ForeName>Antoine</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Lyon Neuroscience Research Center INSERM U1028, CNRS UMR5292, Lyon University, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lautenschlager</LastName><ForeName>Nicola T</ForeName><Initials>NT</Initials><AffiliationInfo><Affiliation>Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>NorthWestern Mental Health, Melbourne Health, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCurry</LastName><ForeName>Susan M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Department of Child, Family, and Population Health Nursing, University of Washington, Seattle, Washington, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meiland</LastName><ForeName>Franka J M</ForeName><Initials>FJM</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Amsterdam University Medical Center, VUmc, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morris</LastName><ForeName>Martha Clare</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush University, Chicago, Illinois, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mueller</LastName><ForeName>Kimberly D</ForeName><Initials>KD</Initials><AffiliationInfo><Affiliation>Wisconsin Alzheimer's Institute, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>Ruth</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Psychology, University of New South Wales, Randwick, Sydney, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Neuroscience Research Australia, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ridel</LastName><ForeName>Gemma</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>The University of East Anglia, Norwich, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spector</LastName><ForeName>Aimee</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Clinical, Educational & Health Psychology, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Steen</LastName><ForeName>Jenny T</ForeName><Initials>JT</Initials><AffiliationInfo><Affiliation>Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Primary and Community Care, Radboud University Medical Center, Nijmegen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tamplin</LastName><ForeName>Jeanette</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Faculty of Fine Arts and Music, University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thompson</LastName><ForeName>Zara</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Faculty of Fine Arts and Music, University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>ISTAART Non-pharmacological Interventions Professional Interest Area</CollectiveName></Author><Author ValidYN="Y"><LastName>Bahar-Fuchs</LastName><ForeName>Alex</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Research on Ageing, Health, and Wellbeing, Research School of Population Health, The Australian National University, Canberra, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 AG051628</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG056102</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>11</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Alzheimers Dement</MedlineTA><NlmUniqueID>101231978</NlmUniqueID><ISSNLinking>1552-5260</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">cognitive rehabilitation</Keyword><Keyword MajorTopicYN="Y">cognitive stimulation therapy</Keyword><Keyword MajorTopicYN="Y">cognitive training</Keyword><Keyword MajorTopicYN="Y">cognitive-behavioral therapy for insomnia</Keyword><Keyword MajorTopicYN="Y">communication treatments</Keyword><Keyword MajorTopicYN="Y">framework</Keyword><Keyword MajorTopicYN="Y">meditation</Keyword><Keyword MajorTopicYN="Y">mild cognitive impairment</Keyword><Keyword MajorTopicYN="Y">multisensory treatments</Keyword><Keyword MajorTopicYN="Y">music-based treatments</Keyword><Keyword MajorTopicYN="Y">neuromodulation</Keyword><Keyword MajorTopicYN="Y">neuropsychiatric</Keyword><Keyword MajorTopicYN="Y">non-pharmacological</Keyword><Keyword MajorTopicYN="Y">nutritional interventions</Keyword><Keyword MajorTopicYN="Y">occupational therapy</Keyword><Keyword MajorTopicYN="Y">physical exercise training</Keyword><Keyword MajorTopicYN="Y">reminiscence therapy</Keyword><Keyword MajorTopicYN="Y">subjective cognitive decline</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>07</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>05</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>11</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>11</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>11</Month><Day>20</Day><Hour>8</Hour><Minute>42</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33215876</ArticleId><ArticleId IdType="doi">10.1002/alz.12188</ArticleId></ArticleIdList><ReferenceList><Title>REFERENCES</Title><Reference><Citation>Alzheimer's Association, Alzheimer's disease facts and figures. 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Mueller</name></country><country name="France"><region name="Région Normandie"><name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gaël" last="Chételat">Gaël Chételat</name></region><name sortKey="Dautricourt, Sophie" sort="Dautricourt, Sophie" uniqKey="Dautricourt S" first="Sophie" last="Dautricourt">Sophie Dautricourt</name><name sortKey="Lutz, Antoine" sort="Lutz, Antoine" uniqKey="Lutz A" first="Antoine" last="Lutz">Antoine Lutz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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